It is a natural process when the body responds to any tissue under ischemic stress, for the cells that are under that stress to go through a molecular process that leads to the creation and secretion of a factor called stromal-derived factor 1 (SDF1). This is released into the bloodstream. The steps include:
· A distress signal (HIF) is induced by hypoxia in the per-infarct zone
· HIF induces synthesis of SDF1 and VEGF, which mobilize CD34+CXCR4+ cells
· The mobolized cells are trophic to the peri-infarct zone, precenting apoptosis and effecting neoangiogenesis
Amorcyte bases AMR-001 on the use of CD34+CXCR4+ cells, and this natural repair mechanism. The body attemts to rescue damaged tissue to prevent vetricular modeling using these cells.
This image shows a heart attack where the cardiomyocytes (depicted in the orange zone) that are surrounding the dead cardiomyocyte in the red, are "calling for help". They're calling for oxygen and more nutrients. As mentioned, the body mobilized CD34+ cells from the bone marrow that coexpress CXCR4+, the receptor for SDF1.