Data References

Phase 1 Clinical Trial for Type 1 Diabetes on
Treg Program Fact Sheet
Abstracts for Peer-Reviewed Literature
Baecher-Allan, C., et al., CD4+CD25high regulatory cells in human peripheral blood. J Immunol, 2001. 167(3): p. 1245-53.
Bennett, C.L., et al., The immune dysregulation, polyendocrinopathy, enteropathy, Xlinked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet, 2001. 27(1): p. 20-1.
Bluestone, J.A. and Q. Tang, How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol, 2005. 17(6): p. 638-42.
Bonelli, M., et al., Phenotypic and Functional Analysis of CD4+CD25-Foxp3+ T Cells in Patients with Systemic Lupus Erythematosus. J Immunol, 2009. 182(3): p. 1689-1695.
Brunstein, C.G., et al., Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood,2011. 117(3): p. 1061-1070.
Cao, T., et al., Ex vivo expanded human CD4+CD25+Foxp3+ regulatory T cells preventlethal xenogenic graft versus host disease (GVHD). Cell Immunol, 2009. 258(1): p. 65-71.
Carrier, Y., et al., Th3 Cells in Peripheral Tolerance. I. Induction of Foxp3-Positive Regulatory T Cells by Th3 Cells Derived from TGF-beta T Cell-Transgenic Mice. J Immunol, 2007. 178(1): p. 179-185.
Chiarini, M., et al., Modulation of the central memory and Tr1-like regulatory T cells in multiple sclerosis patients responsive to interferon-beta therapy. Multiple Sclerosis Journal, 2011.
De Santis, G., et al., Altered miRNA expression in T regulatory cells in course of multiplesclerosis. J Neuroimmunol, 2010. 226(1-2): p. 165-71.
Di Ianni, M., et al., Tregs prevent GVHD and promote immune reconstitution in HLA haploidentical transplantation. Blood., 2011. 117(14): p. 3921-8. Epub 2011 Feb 3.
Engler, J.B., et al., Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus. Annals of the Rheumatic Diseases, 2011.
Fazekas de St Groth, B., et al., Flow cytometric detection of human regulatory T cells. Methods Mol Biol, 2011. 707: p. 263-79.
Golshayan, D., et al., In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. Blood, 2007. 109(2): p. 827-835.
Goodman, W.A., et al., IL-6 Signaling in Psoriasis Prevents Immune Suppression by Regulatory T Cells. J Immunol, 2009. 183(5): p. 3170-3176.
Hartigan-O’Connor, D.J., et al., Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods, 2007. 319(1-2): p. 41-52.
Hippen, K.L., et al., Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity. Science Translational Medicine, 2011. 3(83): p. 83ra41.
Hoffmann, P., et al., Only the CD45RA+ subpopulation of CD4+CD25 high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood, 2006. 108(13): p.4260-7.
Horwitz, D.A., S.G. Zheng, and J.D. Gray, The role of the combination of IL-2 and TGFbeta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets. J Leukoc Biol, 2003. 74(4): p. 471-8.
June, C.H. and B.R. Blazar, Clinical application of expanded CD4(+)25(+) cells. Semin Immunol, 2006. 18(2): p. 78-88.
Kawashiri, S.-Y., et al., CD4+CD25(high)CD127(low/-) Treg Cell Frequency from Peripheral Blood Correlates with Disease Activity in Patients with Rheumatoid Arthritis. The Journal of Rheumatology, 2011. 38(12): p. 2517-2521.
Levings, M.K. and M.G. Roncarolo, T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties. J Allergy Clin Immunol, 2000. 106(1 Pt 2): p. S109-12.
Marek-Trzonkowska, N., et al., Administration of CD4+CD25highCD127− Regulatory T Cells Preserves β-Cell Function in Type 1 Diabetes in Children. Diabetes Care, 2012.
Mathian, A., et al., Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions. Annals of the Rheumatic Diseases, 2012. 71(7): p. 1227-1234.
Mendel, I. and E.M. Shevach, The IL-10-producing competence of Th2 cells generated in vitro is IL-4 dependent. Eur J Immunol, 2002. 32(11): p. 3216-24.
Putnam, A.L., et al., Expansion of Human Regulatory T Cells from Patients with Type 1 Diabetes. Diabetes, 2008: p. 1108-1168.
Sakaguchi, S., et al., Regulatory T cells: how do they suppress immune responses? Int. Immunol., 2009: p. dxp095.
Scalapino, K.J., et al., Suppression of Disease in New Zealand Black/New Zealand White Lupus-Prone Mice by Adoptive Transfer of Ex Vivo Expanded Regulatory T Cells. JImmunol, 2006. 177(3): p. 1451-1459.
Sumida, Y., et al., Preparation of functionally preserved CD4+ CD25high regulatory Tcells from leukapheresis products from ulcerative colitis patients, applicable to regulatory T-cell transfer therapy. Cytotherapy, 2008. 10(7): p. 698-710.
Takahashi, T., et al., Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking theiranergic/suppressive state. Int Immunol, 1998. 10(12): p. 1969-80.
Tamosiuniene, R., et al., Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension. Circulation Research, 2011.
Tang, Q. and J.A. Bluestone, The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol, 2008. 9(3): p. 239-244.
Tang, Q., et al., In vitro-expanded antigen-specific regulatory T cells suppressautoimmune diabetes. J Exp Med, 2004. 199(11): p. 1455-65.
Thompson, J.A., D. Perry, and T.M. Brusko, Autologous regulatory T cells for the treatment of type 1 diabetes. Curr Diab Rep, 2012. 12(5): p. 623-32.
Tosiek, M.J., et al., CD4+CD25+Foxp3+ Regulatory T Cells Are Dispensable for Controlling CD8+ T Cell-Mediated Lung Inflammation. J Immunol, 2011 186:6106-6118.
Trenado, A., et al., Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. JImmunol, 2006. 176(2): p. 1266-73.
Trzonkowski, P., et al., First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- Tregulatory cells. Clin Immunol, 2009. 133(1): p. 22-6.
Trzonkowski, P., et al., Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy. Cytometry A, 2009. 75(3): p. 175-88.
Veldman, C., A. Nagel, and M. Hertl, Type I regulatory T cells in autoimmunity and inflammatory diseases. Int Arch Allergy Immunol, 2006. 140(2): p. 174-83.
Wildin, R.S., et al., X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet, 2001. 27(1): p. 18-20.
Wright, G.P., et al., Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proceedings of the National Academy of Sciences, 2009. 106(45): p. 19078-19083.
Yagi, H., et al., Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol, 2004. 16(11): p. 1643-56.
Zheng, S.G., et al., CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGFbeta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. JImmunol, 2004. 172(3): p. 1531-9.
Zheng, S.G., J. Wang, and D.A. Horwitz, Cutting Edge: Foxp3+CD4+CD25+ Regulatory TCells Induced by IL-2 and TGF-{beta} Are Resistant to Th17 Conversion by IL-6. J Immunol, 2008. 180(11): p. 7112-7116.

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